uqdi Seminar series - dr cedric tremblay
Title:
Multilateral Targeting of Leukemia-Propagating Cells: Novel strategies to overcome resistance and prevent relapse in leukemia
Dr Cedric Tremblay completed his PhD in Molecular and Cellular Biology (Medicine) at Laval University, Quebec City, Canada in 2008. He was awarded a national Health Research Fund of Quebec (FRSQ) postgraduate scholarship (2004-2008) and training award from the Foundation for Research into Children’s Diseases (2007-2008) at the Laval University Hospital Research Centre (2004-2007) which used animal models to study DNA repair in hematopoiesis. Cedric Tremblay was awarded the prestigious Excellence prize in Pediatric Research, which is annually attributed to recognize the unique contribution of scientists working for the improvement of children health, at the 26th Ball of Stars of the Foundation of Stars in 2008. He was awarded a Terry Fox Foundation fellowship from the Canadian Cancer Society for postdoctoral studies in the laboratory of Dr Trang Hoang at the Institute for Research in Immunology and Cancer – University of Montreal, Canada (2008-2011) to study the role of the oncogenes SCL, LMO1 and NOTCH1 in hematopoiesis and leukemia. In 2011, Cedric Tremblay relocated to the Australian Centre for Blood Diseases (ACBD), in the Department of Haematology, Monash University in the team of Associate Professor David Curtis to investigate the molecular mechanisms involved in the development of malignant stem cells. Cedric Tremblay was recently appointed as a research fellow at the ACBD and awarded a research Grant-in Aid from the Leukaemia Foundation of Australia to establish a research program focused on the role of signalling pathways in T-cell Acute Lymphoblastic Leukemia (T-ALL).
Dr Tremblay is dedicated to identify the molecular mechanisms that control the fate of normal and malignant hematopoietic stem cells. Over the past 10 years, he has extensively used different mouse models to dissect the role of signaling pathways in the regulation of the homeostasis in hematopoietic cells and in hematological malignancies. Specific areas of expertise include the regulation of cytokine signaling pathways and endocytosis in T-ALL, the role of bHLH transcription factor complexes and cell cycle regulators to control the fate of normal and malignant hematopoietic stem cells.
