Interactions of the epithelium and stroma that drive breast cancer development 

Since joining the Mayo Clinic in 2005, Dr Radisky has focused his research program on identify the microenvironmental factors that underlie breast and lung cancer cell growth and metastasis using cells cultured under physiological conditions that mimic the tumor microenvironment, sophisticated transgenic animal models in which key cancer-causing genes can be induced and modulated, and well-annotated human tumor biopsy samples through which he can directly evaluate the specificity and potential therapeutic benefit of targeting the processes discovered in cell culture and mouse models.

His findings have identified key MMP-induced genes as coconspirators of oncogenic mutations in the pancreatic cells in orchestrating pancreatic cancer tumorigenesis and progression, both through activation of cancer cells themselves, and by triggering the tumorigenic microenvironment. His findings also point to methods for inhibition of these pathways as potential anticancer therapeutic strategies. Dr Radisky's research has been supported by grants from the Department of Defense, the National Institutes of Health, the Florida Department of Health and several private foundations. 

> RSVP: www.derekradisky.eventbrite.com.au

> Zoom (video) link for distributed sites: Join from a PC, Mac, iOS or Android: https://qut.zoom.us/j/445927940. **IHBI @ KG can link via Zoom in KG-Q321

Would you like to arrange a meeting with Derek before his seminar in Tuesday afternoon? Please contact the organiser Professor Rik Thompson, Associate Director, Institute of Health and Biomedical Innovation (IHBI) on [email protected]