Projects
About me
Associate Professor Ingrid Winkler is a Senior Research Fellow and head of the Stem Cells and Cancer group at Mater Research, Brisbane, Australia.
Ingrid Winkler’s research focuses on understanding how micro-environments protect and instruct Stem Cells. Her innovative research has already led to several discoveries, such as a novel strategy to protect normal Haematopoietic Stem Cells from chemotherapy or radiation damage. Research which may lead to a novel strategy to i. Potentially alleviate the life-threatening side-effects of cancer therapies, and ii. New ways to sensitise cancer cells to standard cancer therapy.
Over the course of her career, Dr Winkler has produced 49 peer-reviewed articles, including a recent landmark study in Nature Medicine 2012, describing a key component of the bone marrow vascular niche (E-selectin) in regulating Haematopoietic Stem Cell self-renewal and chemo-sensitivity and last year her research was recognized to be among ‘Ten of the Best Research Projects’in Australia by the National Health & Medical Research Council.
Publications
Selected Publications
Winkler IG, Barbier V, Nowlan B, et al. Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance. Nature Medicine. 2012;18(11):1651-1657.
Winkler IG, Sims NA, Pettit AR, et al. Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs. Blood. 2010. 116(23):4815-4828.
Winkler IG, Barbier V, Wadley R, Zannettino AC, Williams S, Levesque JP. Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches. Blood. 2010. 116(3):375-385.
Levesque JP, Winkler IG. Mobilization of hematopoietic stem cells: state of the art. Curr Opin Organ Transplant. 2008;13(1):53-58.
Winkler IG, Pettit AR, Raggatt LJ, et al. Hematopoietic stem cell mobilizing agents G-CSF, cyclophosphamide or AMD3100 have distinct mechanisms of action on bone marrow HSC niches and bone formation. Leukemia. 2012;26(7):1594-1601.
Winkler IG, Bendall LJ, Forristal CE, et al. B-lymphopoiesis is stopped by mobilizing doses of G-CSF and is rescued by overexpression of the anti-apoptotic protein Bcl2. Haematologica. 2012; 98(3):325-333.
